Proregenerative Properties of ECM Molecules
نویسنده
چکیده
After traumatic injuries to the nervous system, regrowing axons encounter a complex microenvironment where mechanisms that promote regeneration compete with inhibitory processes. Sprouting and axonal regrowth are key components of functional recovery but are often counteracted by inhibitory molecules. This review covers extracellular matrix molecules that support neuron axonal outgrowth.
منابع مشابه
Simulated Microgravity Condition Alters the Gene Expression of some ECM and Adhesive Molecules in Adipose-Derived Stem Cells
Adipose-derived stem cells (ADSCs) are widely used for tissue engineering and regenerative medicine. The beneficial effects of ADSCs on wound healing have already been reported. Remodeling of extracellular matrix (ECM) is the most important physiological event during the wound healing. ECM is sensitive to mechanical stresses and the expression of its components can be therefore influenced. The ...
متن کاملساختار و مراحل ترمیم پوست
Skin injury caused by burns, surgery and other traumas may result in unpleasant psychological experiences and be reflected in behaviors. Extracellular matrix (ECM) is the largest component of natural skin which is gel-like and is produced by skin cells. ECM synthesis is a key factor for filling up skin wounds such as burns, leishmaniasis, chicken pox, acne, etc. ECM is composed of a variety of ...
متن کاملمطالعه تغییرات گلیکوزآمینوگلیکان های ماتریکس خارج سلولی در روند تکامل پالپ دندان در موش
Mesenchymal- epithelial interactions during embryogenesis have been shown to be important in the fetal development of many organs. Identification of molecules that modulate these interactions is key to our understanding of the pathological conditions. The major groups of extracellular matrix (ECM) molecules characterized are glycosaminoglycans that candidate for morphogenesis and differentiatio...
متن کاملExtracellular matrix molecules: potential targets in pharmacotherapy.
The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and noncollagenous glycoproteins. In addition to being necessary structural components, ECM molecules exhibit important functional roles in the control of key cellular events such as adhesion, migration, proliferati...
متن کاملThe extracellular matrix as a biologic scaffold material.
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) have received significant attention for their potential therapeutic applications. The full potential of the ability of ECM scaffolds to promote constructive remodeling will not be realized, however, until an understanding of the biology and the external influences that affect biology, are better achieved. The factors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013